HRID1828530

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(C)OC(=O)C=P(c1ccccc1)(c1ccccc1)c1ccccc1

HCID256127

tert-Butyl (triphenylphosphoranylidene) acetate

C24H25O2P

结构：COc1c(CCc2nc(C(C)C)cs2)ccn2c(=O)c(C=O)c(N3CCOCC3)nc12

HCID22063693

未命名化合物

2 次

PRODUCTS

生成物

结构：COc1c(CCc2nc(C(C)C)cs2)ccn2c(=O)c(/C=C/C(=O)OC(C)(C)C)c(N3CCOCC3)nc12

HCID86588148

未命名化合物

收率 57%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

溶剂HCID8028

Tetrahydrofuran

C4H8O

CONDITIONS

反应条件

温度: 80 °C

PROCEDURE

实验过程

The 8-[2-(4-isopropyl-1,3-thiazol-2-yl)ethyl]-9-methoxy-2-morpholino-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carbaldehyde (300 mg) obtained in (H) was dissolved in tetrahydrofuran (4 ml) and dimethylformamide (1 ml), added with (tert-butoxy-carbonylmethylene)triphenylphosphorane (767 mg), and stirred at 80° C. for 15 hours. After the solvent was evaporated, the residue was purified by silica gel column chromatography to obtain the title compound (209 mg) as yellow powder.

WORKUP

后处理

customAfter the solvent was evaporated
customthe residue was purified by silica gel column chromatography

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-3ea7837a06174f2cb8599b89d888f654
来源数据集: uspto-grants-2006_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07056917B2
来源说明: uspto-grants-2006_06

反应 SMILES

[CH:1]([C:4]1[N:5]=[C:6]([CH2:9][CH2:10][C:11]2[CH:29]=[CH:28][N:14]3[C:15](=[O:27])[C:16]([CH:25]=O)=[C:17]([N:19]4[CH2:24][CH2:23][O:22][CH2:21][CH2:20]4)[N:18]=[C:13]3[C:12]=2[O:30][CH3:31])[S:7][CH:8]=1)([CH3:3])[CH3:2].[C:32]([O:36][C:37]([CH:39]=P(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)=[O:38])([CH3:35])([CH3:34])[CH3:33]>O1CCCC1.CN(C)C=O>[CH:1]([C:4]1[N:5]=[C:6]([CH2:9][CH2:10][C:11]2[CH:29]=[CH:28][N:14]3[C:15](=[O:27])[C:16](/[CH:25]=[CH:39]/[C:37]([O:36][C:32]([CH3:33])([CH3:34])[CH3:35])=[O:38])=[C:17]([N:19]4[CH2:24][CH2:23][O:22][CH2:21][CH2:20]4)[N:18]=[C:13]3[C:12]=2[O:30][CH3:31])[S:7][CH:8]=1)([CH3:3])[CH3:2]