Trifluoroacetic acid → HCID 178493958, compound

HRID 1828537Notes

Reaction equation

HRID 1828537 reaction equation
[CH:1]([C:4]1[N:5]=[C:6]([CH2:9][CH2:10][C:11]2[CH:37]=[CH:36][N:14]3[C:15](=[O:35])[C:16]([C:21]4[N:22]=[N:23][N:24](CC5C=CC(OC)=CC=5)[N:25]=4)=[C:17]([O:19][CH3:20])[N:18]=[C:13]3[CH:12]=2)[S:7][CH:8]=1)([CH3:3])[CH3:2].FC(F)(F)C(O)=O.C1(OC)C=CC=CC=1>>[CH:1]([C:4]1[N:5]=[C:6]([CH2:9][CH2:10][C:11]2[CH:37]=[CH:36][N:14]3[C:15](=[O:35])[C:16]([C:21]4[NH:25][N:24]=[N:23][N:22]=4)=[C:17]([O:19][CH3:20])[N:18]=[C:13]3[CH:12]=2)[S:7][CH:8]=1)([CH3:3])[CH3:2]

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 7519AnisoleHCID 22063653HCID 22063653, compound2×

Product 1

HCID 178493958HCID 178493958, compoundYield 31.3%

Procedure

The 8-[2-(4-isopropyl-1,3-thiazol-2-yl)ethyl]-2-methoxy-3-[2-(4-methoxy-benzyl)-2H-1,2,3,4-tetrazol-5-yl]-4H-pyrido[1,2-a]pyrimidin-4-one (5 mg) obtained in (A) was added with trifluoroacetic acid (0.3 ml) and anisole (0.1 ml) and stirred for 2 days. The solvent was evaporated under reduced pressure, and the residue was added with hexane and ethyl acetate. Insoluble solids were collected by filtration and dried to obtain the title compound (1.2 mg).

Workup

  1. customThe solvent was evaporated under reduced pressure
  2. additionthe residue was added with hexane and ethyl acetate
  3. filtrationInsoluble solids were collected by filtration
  4. customdried

Sources & evidence

ORD record
ord-e2697f7f96ae48f38a53b5aed1eaa938
Source dataset
uspto-grants-2006_06
Patent number
US07056917B2

Reaction notes

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