1,8-Diazabicyclo(5.4.0)undec-7-ene → HCID 86588153, compound

HRID 1828550Notes

Reaction equation

HRID 1828550 reaction equation
[CH:1]([C:3]1[C:8](=[O:9])[N:7]2[CH:10]=[CH:11][C:12]([CH2:14][CH2:15][C:16]3[S:17][CH:18]=[C:19]([CH:21]([CH3:23])[CH3:22])[N:20]=3)=[CH:13][C:6]2=[N:5][C:4]=1[N:24]1[CH2:29][CH2:28][CH2:27][CH:26]([C:30]([O-])=[O:31])[CH2:25]1)=O.FC(F)(F)COP([CH2:45][C:46]([O:48][CH3:49])=[O:47])(=O)OCC(F)(F)F.C1CCN2C(=NCCC2)CC1.[Cl-].[Li+]>O1CCCC1>[CH:30]([CH:26]1[CH2:27][CH2:28][CH2:29][N:24]([C:4]2[N:5]=[C:6]3[CH:13]=[C:12]([CH2:14][CH2:15][C:16]4[S:17][CH:18]=[C:19]([CH:21]([CH3:22])[CH3:23])[N:20]=4)[CH:11]=[CH:10][N:7]3[C:8](=[O:9])[C:3]=2/[CH:1]=[CH:45]/[C:46]([O:48][CH3:49])=[O:47])[CH2:25]1)=[O:31]

Participants

6

Reactant 4

HCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 184894Nsc 634137HCID 433294Lithium ChlorideHCID 22063730HCID 22063730, compound

Product 1

HCID 86588153HCID 86588153, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

1-{3-Formyl-8-[2-(4-isopropyl-1,3-thiazol-2-yl)ethyl]-4-oxo-4H-pyrido[1,2-a]pyrimidin-2-yl}-3-piperidylformate (94.0 mg, 0.207 mmol) and bis(2,2,2-trifluoroethyl)-(methoxycarbonylmethyl)phosphonoate (0.131 ml, 0.620 mmol) were dissolved in tetrahydrofuran (2 ml), added with DBU (0.085 ml, 0.620 mmol) and lithium chloride (26.3 mg, 0.620 mmol), and then the mixture was stirred at room temperature for 1 hour.

Sources & evidence

ORD record
ord-1f78369b4feb436f8274ae9c4b42a09b
Source dataset
uspto-grants-2006_06
Patent number
US07056917B2

Reaction notes

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