Formic Acid → Formamide, N-(2-phenylethyl)-

HRID 1828770Notes

Reaction equation

[C:1]1([CH2:7][CH2:8][NH2:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH:10](O)=[O:11]>>[C:1]1([CH2:7][CH2:8][NH:9][CH:10]=[O:11])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

Reactant 2

HCID 284Formic Acid

HCID 1001Phenethylamine

Product 1

HCID 140995Formamide, N-(2-phenylethyl)-Yield 89.1%

Conditions

Temperature: 200 °C

Procedure

A mixture of phenylethylamine (20.0 g, 0.165 mol) and formic acid (49.4 ml, 1.309 mol) was slowly heated to 200° C. Excess water and formic acid were distilled off in the process. The mixture was then kept at 200° C. for 1 hour, and the product was distilled under reduced pressure, giving a colourless oil (22.0 g, 0.147 mol, 89%).

Workup

distillationExcess water and formic acid were distilled off in the process
distillationthe product was distilled under reduced pressure

Sources & evidence

ORD record: ord-021e98b9817348e791eec977f6caba93
Source dataset: uspto-grants-2006_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07060707B2

Reaction notes

Loading…