反应详情

To a solution of 4-chloro-1-(2-chloro-4-iodobenzyl)-2-methylimidazole 5-carbaldehyde (1.01 g) in tetrahydrofuran (10 ml) was added methyl (triphenylphosphoranylidene)acetate (1.27 g) and the mixture was refluxed under heating for 4 hr. The solvent was evaporated and the residue was purified by silica gel column chromatography (hexane/ethyl acetate=3/1) to give methyl (E)-3-(4-chloro-1-(2-chloro-4-iodobenzyl)-2-methylimidazol-5-yl)-2-propenate (974 mg) as a white powder.

1. temperaturethe mixture was refluxed
2. temperatureunder heating for 4 hr
3. customThe solvent was evaporated
4. customthe residue was purified by silica gel column chromatography (hexane/ethyl acetate=3/1)