反应详情

A mixture of 2-fluoro-4-hydroxy-benzonitrile (6 g, 43.8 mmol), palladium hydroxide (600 mg), ethanol (60 ml) and 2N hydrochloric acid (6 ml) was hydrogenated (60 psi) for 18 hours. The mixture was filtered through Arbocel® and the filter cake was washed with methanol and the filtrates were evaporated in-vacuo. The residue was triturated with diethylether to give 4-aminomethyl-3-fluoro phenol hydrochloride (4.71 g).

1. customfor 18 hours
2. filtrationThe mixture was filtered through Arbocel®
3. washthe filter cake was washed with methanol
4. customthe filtrates were evaporated in-vacuo
5. customThe residue was triturated with diethylether