Hydrochloric Acid → HCID 10228813, compound

HRID 1829127Notes

Reaction equation

HRID 1829127 reaction equation
[ClH:1].Cl.Cl.Cl.C(OC([N:12]1[CH2:16][C@@H:15]([N:17]2[CH2:22][CH2:21][N:20]([C:23]3[CH:28]=[CH:27][C:26]([C:29]([O:31]CC)=[O:30])=[CH:25][N:24]=3)[CH2:19][CH2:18]2)[CH2:14][C@H:13]1[C:34]([N:36]1[CH2:40][CH2:39][S:38][CH2:37]1)=[O:35])=O)(C)(C)C.Cl.Cl.Cl.C(OC(C1C=CC(N2CCN([C@@H]3CN[C@H](C(N4CCSC4)=O)C3)CC2)=NC=1)=O)C>>[ClH:1].[ClH:1].[ClH:1].[C:29]([C:26]1[CH:27]=[CH:28][C:23]([N:20]2[CH2:19][CH2:18][N:17]([C@@H:15]3[CH2:16][NH:12][C@H:13]([C:34]([N:36]4[CH2:40][CH2:39][S:38][CH2:37]4)=[O:35])[CH2:14]3)[CH2:22][CH2:21]2)=[N:24][CH:25]=1)([OH:31])=[O:30]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 67505982HCID 67505982, compoundHCID 69621005HCID 69621005, compound

Product 1

HCID 10228813HCID 10228813, compound

Procedure

6 mol/L Hydrochloric acid was added to 3-{(2S,4S)-1-tert-butoxycarbonyl-4-[4-(5-ethoxycarbonyl-2-pyridyl)-1-piperazinyl]-2-pyrrolidinylcarbonyl}-1,3-thiazolidine trihydrochloride [product of Example 211 (2), 1.00 g] and the mixture was refluxed for 2 hr. The solvent was evaporated under reduced pressure, and the residue was purified by HPLC. This was converted to hydrochloride with 4 mol/L hydrochloric acid-1,4-dioxane to give the title compound (158 mg) as a white powder.

Workup

  1. temperaturethe mixture was refluxed for 2 hr
  2. customThe solvent was evaporated under reduced pressure
  3. customthe residue was purified by HPLC

Sources & evidence

ORD record
ord-d5c71dbce36e4787ad735a8958ebf871
Source dataset
uspto-grants-2006_06
Patent number
US07060722B2

Reaction notes

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