Lithium hydroxide, monohydrate → HCID 22053877, compound

HRID 1829616Notes

Reaction equation

HRID 1829616 reaction equation
C([O:3][C:4]([C:6]1[C:10]([CH3:11])=[CH:9][S:8][C:7]=1[NH:12][C:13]([O:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23])=[O:14])=[O:5])C.O[Li].O>C(O)C.C1COCC1>[CH3:11][C:10]1[C:6]([C:4]([OH:5])=[O:3])=[C:7]([NH:12][C:13]([O:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23])=[O:14])[S:8][CH:9]=1

Participants

5

Reactant 2

HCID 168937Lithium hydroxide, monohydrateHCID 21030768HCID 21030768, compound

Product 1

HCID 22053877HCID 22053877, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

(8.1) To a stirring solution of 4-methyl-2-octyloxycarbonylamino-thiophene-3-carboxylic acid ethyl ester (254 mg, 0.74 mmol) in ethanol (2 mL) and THF (2 mL) was added LiOH—H2O (31 mg, 0.74 mmol). The reaction was stirred at RT for 5 days, and then solvent was removed under reduced pressure to give a solid. The product was taken on without further purification: 1H NMR (CDCl3) δ 6.02 (s, 1H), 4.07 (t, 2H, J=6.6 Hz), 2.32 (s, 3H), 1.60-1.40 (m, 2H), 1.27 (bs, 10H), 0.86 (t, 3H, J=6.6 Hz).

Workup

  1. customsolvent was removed under reduced pressure
  2. customto give a solid
  3. customThe product was taken on without further purification

Sources & evidence

ORD record
ord-b90f00fc1c464879baca3c2212d596ea
Source dataset
uspto-grants-2006_06
Patent number
US07064122B2

Reaction notes

Loading…