反应详情

Heat [6-(9-Chloro-3-methyl-4-oxo-5H-isoxazolo[4,3-c]quinolin-5-yl)-pyridin-2-yl]-acetic acid ethyl ester (0.359 g, 0.9 mmol), MeOH (4.5 ml), THF (0.5ml), and 1N NaOH (1.8 ml, 1.8 mmol) at 50° C. for 2 h. Cool to room temperature, dilute with H2O, and acidify (conc. HCl) to less than pH 3. Extract with EtOAc twice and wash the combined extracts (H2O then brine), dry (MgSO4), filter, and concentrate giving the title compound (0.338 g, 100%). Use this material without further purification. Mass Spectrum (FIA) (m/z) 370.0 [M+1]

1. extractionExtract with EtOAc twice
2. washwash the combined extracts (H2O
3. dry with materialbrine), dry (MgSO4)
4. filtrationfilter
5. concentrationconcentrate