Trifluoroacetic acid → 2-amino-1-benzooxazol-2-yl-butan-1-one TFA salt

HRID 1830136Notes

Reaction equation

HRID 1830136 reaction equation
C(OC(=O)[NH:7][CH:8]([CH:11]([C:13]1[O:14][C:15]2[CH:21]=[CH:20][CH:19]=[CH:18][C:16]=2[N:17]=1)[OH:12])[CH2:9][CH3:10])(C)(C)C.[C:23]([OH:29])([C:25]([F:28])([F:27])[F:26])=[O:24]>C(Cl)Cl>[OH:29][C:23]([C:25]([F:28])([F:27])[F:26])=[O:24].[NH2:7][CH:8]([CH2:9][CH3:10])[C:11]([C:13]1[O:14][C:15]2[CH:21]=[CH:20][CH:19]=[CH:18][C:16]=2[N:17]=1)=[O:12]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 21031071[1-(Benzooxazol-2-yl-hydroxy-methyl)-propyl]-carbamic acid tert-butyl ester

Product 1

HCID 866111312-amino-1-benzooxazol-2-yl-butan-1-one TFA salt

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

[1-(Benzooxazol-2-yl-hydroxy-methyl)-propyl]-carbamic acid tert-butyl ester (275 mg, 0.89 mmol) and MeCl2 (5 ml) were mixed and TFA (1 ml) was added at room temperature. After stirring for 1 hour, the solvent and excess TFA were removed under vacuum to produce 260 mg of 2-amino-1-benzooxazol-2-yl-butan-1-one TFA salt.

Workup

  1. customthe solvent and excess TFA were removed under vacuum

Sources & evidence

ORD record
ord-98dfa42e137d4fa58414dac727e9c6a5
Source dataset
uspto-grants-2006_06
Patent number
US07064123B1

Reaction notes

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