4-Aminopyridine → HCID 22054168, compound

HRID 1830446Notes

Reaction equation

HRID 1830446 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][N:5]=[CH:4][CH:3]=1.C(N(CC)CC)C.[Cl-].ClC1N(C)CC[NH+]1C.[CH3:24][C:25]1[C:30](=[O:31])[C:29]([CH3:32])=[C:28]([CH3:33])[C:27](=[O:34])[C:26]=1[CH2:35][C:36]1[CH:37]=[CH:38][C:39]([O:45]C(=O)C)=[C:40]([CH:44]=1)[C:41](O)=[O:42]>O.C(Cl)Cl>[N:5]1[CH:6]=[CH:7][C:2]([NH:1][C:41](=[O:42])[C:40]2[CH:44]=[C:36]([CH2:35][C:26]3[C:27](=[O:34])[C:28]([CH3:33])=[C:29]([CH3:32])[C:30](=[O:31])[C:25]=3[CH3:24])[CH:37]=[CH:38][C:39]=2[OH:45])=[CH:3][CH:4]=1

Participants

7

Reactant 4

HCID 17274-AminopyridineHCID 8471TriethylamineHCID 109867151H-Imidazolium, 2-chloro-4,5-dihydro-1,3-dimethyl-, chlorideHCID 22054145HCID 22054145, compound

Product 1

HCID 22054168HCID 22054168, compoundYield 7%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6344DichloromethaneSolvent

Procedure

4-Aminopyridine (0.103 g, 1.096 mmol), triethylamine (0.111 g, 1.096 mmol) and 2-chloro-1,3-dimethylimidazolinium chloride (0.185 g, 1.096 mmol) were added to a methylene chloride solution (100 ml) of 5-(3,5,6-trimethyl-1,4-benzoquinon-2-yl)methyl-2-acetoxybenzoic acid (0.250 g, 0.730 mmol) and the resulting solution was stirred at room temperature for 12 hours. The reaction solution was poured into ice water and then extracted with methylene chloride. The extract was washed with water and then dried, and the solvent was removed by distillation. The obtained residue was dissolved in methanol (3 ml) and after adding thereto an aqueous saturated sodium hydrogencarbonate solution (3 ml), the solution was stirred at room temperature for 3 hours. After the completion of reaction, the reaction solution was diluted with water and then extracted with ethyl acetate. The extract was washed with water and then dried, and the solvent was removed by distillation. The obtained residue was purified by preparative thin-layer chromatography (chloroform:methanol=95:5) to obtain the titled compound (0.020 g, 0.049 mmol, 7%).

Workup

  1. extractionextracted with methylene chloride
  2. washThe extract was washed with water
  3. customdried
  4. customthe solvent was removed by distillation
  5. dissolutionThe obtained residue was dissolved in methanol (3 ml)
  6. additionafter adding
  7. stirringan aqueous saturated sodium hydrogencarbonate solution (3 ml), the solution was stirred at room temperature for 3 hours
  8. customAfter the completion of reaction
  9. extractionextracted with ethyl acetate
  10. washThe extract was washed with water
  11. customdried
  12. customthe solvent was removed by distillation
  13. customThe obtained residue was purified by preparative thin-layer chromatography (chloroform:methanol=95:5)

Sources & evidence

ORD record
ord-e51076889f7649b39bfa892dcb4d31d2
Source dataset
uspto-grants-2006_06
Patent number
US07064124B2

Reaction notes

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