Oxalyl chloride → 4-Cyano-3-fluorophenyl 7-propylphenanthrene-2-carboxylate

HRID 1830484Notes

Reaction equation

HRID 1830484 reaction equation
[CH2:1]([C:4]1[CH:17]=[CH:16][C:15]2[C:14]3[C:9](=[CH:10][C:11]([C:18]4C=C(F)C(F)=C(F)C=4)=[CH:12][CH:13]=3)[CH2:8][CH2:7][C:6]=2[CH:5]=1)[CH2:2][CH3:3].C(Cl)(=O)C(Cl)=[O:29].[F:33][C:34]1[CH:41]=[C:40]([OH:42])[CH:39]=[CH:38][C:35]=1[C:36]#[N:37]>>[CH2:1]([C:4]1[CH:5]=[C:6]2[C:15]([C:14]3[CH:13]=[CH:12][C:11]([C:18]([O:42][C:40]4[CH:39]=[CH:38][C:35]([C:36]#[N:37])=[C:34]([F:33])[CH:41]=4)=[O:29])=[CH:10][C:9]=3[CH:8]=[CH:7]2)=[CH:16][CH:17]=1)[CH2:2][CH3:3]

Participants

4

Reactant 3

HCID 65578Oxalyl chlorideHCID 27346752-Fluoro-4-hydroxybenzonitrileHCID 220446632-Propyl-7-(3,4,5-trifluorophenyl)-9,10-dihydrophenanthrene

Product 1

HCID 210329194-Cyano-3-fluorophenyl 7-propylphenanthrene-2-carboxylate

Procedure

2-iodo-7-propylphenanthrene produced in Example 1 was reacted with oxalyl dichloride, and subsequently reacted with 2-fluoro-4-hydroxybenzonitrile to yield 4-cyano-3-fluorophenyl 7-propylphenanthrene-2-carboxylate

Sources & evidence

ORD record
ord-0af4bddb0b964880b55fb92545a86803
Source dataset
uspto-grants-2006_06
Patent number
US07067179B1

Reaction notes

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