Diethyl Ether → HCID 22049722, compound

HRID 1830869Notes

Reaction equation

HRID 1830869 reaction equation
C[C:2]1[C:3]([C:11]2[S:12][CH:13]=[C:14]([C:16]3[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][CH:17]=3)[N:15]=2)=[C:4]([CH:8]=[CH:9][N:10]=1)C(O)=O.[CH3:23][Mg]I.CC[O:28][CH2:29][CH3:30]>O1CCCC1>[Cl:22][C:19]1[CH:18]=[CH:17][C:16]([C:14]2[N:15]=[C:11]([C:3]3[CH:2]=[N:10][CH:9]=[CH:8][C:4]=3[C:29]([OH:28])([CH3:30])[CH3:23])[S:12][CH:13]=2)=[CH:21][CH:20]=1

Participants

5

Reactant 3

HCID 3283Diethyl EtherHCID 22049678HCID 22049678, compoundHCID 178418373HCID 178418373, compound

Product 1

HCID 22049722HCID 22049722, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The compound (141) (857 mg, 2.5 mmol) was dissolved in anhydrous tetrahydrofuran (5 ml) and a 2M solution (3 ml, 6.0 mmol) of MeMgI in ether was added under ice-cooling. The reaction mixture was stirred at room temperature for one hr.

Workup

  1. temperaturecooling

Sources & evidence

ORD record
ord-6d0020f019c949d7937196c016ceb833
Source dataset
uspto-grants-2006_06
Patent number
US07067537B2

Reaction notes

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