Sodium Bicarbonate → HCID 22049711, compound

HRID 1830902Notes

Reaction equation

HRID 1830902 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][N:5]=[CH:4][C:3]=1[C:8]1[S:9][CH:10]=[C:11]([C:13]2[CH:14]=[C:15]([CH:18]=[CH:19][CH:20]=2)[C:16]#[N:17])[N:12]=1.C(=O)([O-])[OH:22].[Na+]>Cl>[CH3:1][C:2]1[CH:7]=[CH:6][N:5]=[CH:4][C:3]=1[C:8]1[S:9][CH:10]=[C:11]([C:13]2[CH:14]=[C:15]([CH:18]=[CH:19][CH:20]=2)[C:16]([NH2:17])=[O:22])[N:12]=1

Participants

4

Reactant 2

HCID 516892Sodium BicarbonateHCID 22049693HCID 22049693, compound

Product 1

HCID 22049711HCID 22049711, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Conditions

Temperature
40 °C

Procedure

3-{2-[4-Methylpyridin-3-yl]-1,3-thiazol-4-yl}benzonitrile (100 mg) was dissolved in conc. hydrochloric acid (4 ml) and the mixture was stirred at 40° C. for 16 hrs. The reaction mixture was added to aqueous sodium hydrogen carbonate and extracted with ethyl acetate. The organic layer was dried and concentrated. The residue was recrystallized from ethyl acetate-methanol to give the title compound (72 mg) as pale-yellow powder crystals.

Workup

  1. extractionextracted with ethyl acetate
  2. customThe organic layer was dried
  3. concentrationconcentrated
  4. customThe residue was recrystallized from ethyl acetate-methanol

Sources & evidence

ORD record
ord-082d38b8f4f54a799b8911a3c68df47d
Source dataset
uspto-grants-2006_06
Patent number
US07067537B2

Reaction notes

Loading…