Methylamine → HCID 22049769, compound

HRID 1830923Notes

Reaction equation

HRID 1830923 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][N:5]=[CH:4][C:3]=1[C:8]1[S:9][CH:10]=[C:11]([C:13]2[CH:14]=[C:15]([CH:19]=[CH:20][CH:21]=2)[C:16]([OH:18])=O)[N:12]=1.S(Cl)(Cl)=O.[CH3:26][NH2:27]>>[CH3:26][NH:27][C:16](=[O:18])[C:15]1[CH:19]=[CH:20][CH:21]=[C:13]([C:11]2[N:12]=[C:8]([C:3]3[CH:4]=[N:5][CH:6]=[CH:7][C:2]=3[CH3:1])[S:9][CH:10]=2)[CH:14]=1

Participants

4

Reactant 3

HCID 6329MethylamineHCID 24386Thionyl ChlorideHCID 22049703HCID 22049703, compound

Product 1

HCID 22049769HCID 22049769, compound

Procedure

By the reaction in the same manner as in Example 60 using 3-[2-(4-methyl-pyridin-3-yl)-1,3-thiazol-4-yl]benzoic acid (256 mg), thionyl chloride (0.09 ml) and aqueous methylamine solution (40%, 5 ml), the title compound (191 mg) was obtained as colorless powder crystals.

Sources & evidence

ORD record
ord-cf0978da721f4382a56f8e5c6493f91c
Source dataset
uspto-grants-2006_06
Patent number
US07067537B2

Reaction notes

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