反应详情

温度

165 °C

A mixture of 4-aminophenol (3.27 g, 30.0 mmol) and 3,3-dimethylglutaric anhydride (4.26 g, 30.0 mmol) was heated in a round bottom flask at 165° C. for 1 h, followed by heating at 180° C. for 7 h. After cooling to room temperature the solid material was dissolved in hot ethanol, activated charcoal was added and the solution was heated at reflux for 1 h. The solid material was removed by hot filtration. The solvent was evaporated and the residue was crystallised (water/ethanol) yielding the title compound (3.51 g, 50%, pink solid).

1. temperatureby heating at 180° C. for 7 h
2. temperatureAfter cooling to room temperature the solid material
3. temperaturethe solution was heated
4. temperatureat reflux for 1 h
5. customThe solid material was removed by hot filtration
6. customThe solvent was evaporated
7. customthe residue was crystallised (water/ethanol)