反应详情

温度

170 °C

A mixture of 4-aminophenol (5.46 g, 50.0 mmol) and cis-1,2-cyclohexanedicarboxylic anhydride (7.71 g, 50.0 mmol) was heated in a round bottom flask at 170° C. for 2 h. After cooling to room temperature the solid material was dissolved in hot ethanol (200 ml), activated charcoal was added and the solution was heated at reflux for 1 h. The solid material was removed by hot filtration. The solvent was partially evaporated. The solids were collected by filtration, washed quickly with a small amount of ethanol and dried in vacuo yielding the title compound (8.52 g, 69%, pink solid).

1. temperatureAfter cooling to room temperature the solid material
2. temperaturethe solution was heated
3. temperatureat reflux for 1 h
4. customThe solid material was removed by hot filtration
5. customThe solvent was partially evaporated
6. filtrationThe solids were collected by filtration
7. washwashed quickly with a small amount of ethanol
8. customdried in vacuo