反应详情

The product from step (b) (40 mg, 70 μmol) was dissolved in anhydrous dichloromethane (2.5 mL) and trifluoroacetic acid (269 μL, 3.5 mmol) was added. The mixture was stirred at room temperature for two hours. 1M Aqueous potassium carbonate (3.5 mL) followed by 0.1M aqueous sodium hydroxide (1 mL) were added and the product was extracted twice with dichloromethane. The precipitate which formed was filtered off, washed with dichloromethane and dried in vacuo at 40° C. overnight resulting in 24 mg (73% yield) of the title compound as an off-white solid.

1. additionwere added
2. extractionthe product was extracted twice with dichloromethane
3. customThe precipitate which formed
4. filtrationwas filtered off
5. washwashed with dichloromethane
6. customdried in vacuo at 40° C. overnight