Potassium Carbonate → HCID 53951689, compound

HRID 1831747Notes

Reaction equation

HRID 1831747 reaction equation
C([O:4][CH2:5][CH2:6][C:7]1[C:8]([Cl:21])=[CH:9][C:10]2[CH:11]3[CH2:20][CH2:19][CH2:18][CH:12]3[C:13](=[O:17])[NH:14][C:15]=2[CH:16]=1)(=O)C.C(=O)([O-])[O-].[K+].[K+]>CO.C(OCC)(=O)C>[Cl:21][C:8]1[C:7]([CH2:6][CH2:5][OH:4])=[CH:16][C:15]2[NH:14][C:13](=[O:17])[CH:12]3[CH2:18][CH2:19][CH2:20][CH:11]3[C:10]=2[CH:9]=1

Participants

5

Reactant 2

HCID 11430Potassium CarbonateHCID 69652744HCID 69652744, compound

Product 1

HCID 53951689HCID 53951689, compoundYield 84.7%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

380 mg (1.2 mmol) of 7-acetoxyethyl-8-chloro-1,2,3,3a,5,9b-hexahydrocyclopenta[c]quinolin-4-one is dissolved in 30 ml of methanol and mixed with 341 mg (2.5 mmol) of potassium carbonate. After 3 days at room temperature, the batch is diluted with ethyl acetate, washed with water, dried (Na2SO4) and concentrated by evaporation in a vacuum. Column chromatography on silica gel with ethyl acetate-ethanol yields 270 mg of product.

Workup

  1. washwashed with water
  2. dry with materialdried (Na2SO4)
  3. concentrationconcentrated by evaporation in a vacuum

Sources & evidence

ORD record
ord-93f253e75eee4d38a512709cc7df9086
Source dataset
uspto-grants-2006_06
Patent number
US07067667B2

Reaction notes

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