反应详情

1.75 g of triphenylphosphine and 1 g of 5-Hydroxy-isophthalic acid dimethyl ester were dissolved in 17 ml of anhydrous THF. The solution was cooled to 0–10° C. and a solution of 1 ml DEAD in 1 ml anhydrous THF was added dropwise over 20 min. The reaction was warmed to RT and stirred for 45 min. A solution of 11.3 ml 2-(2,4-Dichlorophenyl)-ethanol in 1 ml anhydrous THF was added with cooling. The reaction was stirred at RT for 16 h, then the solvents were removed under reduced pressure. The residue was treated with n-heptane:ethyl acetate/1:1. The filtrate was dried under reduced pressure and the product was purified by silica gel chromatography, eluting with n-heptane:ethyl acetate/4:1 to n-heptane:ethyl acetate/3:1.

1. temperatureThe solution was cooled to 0–10° C.
2. temperaturewith cooling
3. stirringThe reaction was stirred at RT for 16 h
4. customthe solvents were removed under reduced pressure
5. additionThe residue was treated with n-heptane
6. customThe filtrate was dried under reduced pressure
7. customthe product was purified by silica gel chromatography
8. washeluting with n-heptane