Hydrochloric Acid → HCID 22052394, Verbindung

HRID 1831789Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1831789
C[O:2][C:3](=[O:25])[C:4]1[CH:13]=[C:12]([O:14][CH2:15][CH2:16][C:17]2[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][C:18]=2[Cl:24])[CH:11]=[C:6]([C:7]([O:9]C)=[O:8])[CH:5]=1.O.O.[OH-].[Li+].Cl>CO>[Cl:24][C:18]1[CH:19]=[C:20]([Cl:23])[CH:21]=[CH:22][C:17]=1[CH2:16][CH2:15][O:14][C:12]1[CH:11]=[C:6]([C:7]([OH:9])=[O:8])[CH:5]=[C:4]([CH:13]=1)[C:3]([OH:25])=[O:2]

Komponenten

6

Edukt 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 168937Lithium hydroxide, monohydrateHCID 696522995-[2-(2,4-Dichloro-phenyl)-ethoxy]-isophthalic acid dimethyl ester

Produkt 1

HCID 22052394HCID 22052394, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Reaktionsbedingungen

Temperatur
50 °C

Versuchsvorschrift

500 mg 5-[2-(2,4-Dichloro-phenyl)-ethoxy]-isophthalic acid dimethyl ester were dissolved in 50 ml of MeOH:water/3:1. Then 1 g of lithium hydroxide monohydrate was added the solution, and the reaction was stirred at RT for 16 h and 2 h at 50° C. The solution was cooled to RT and then acidified with half-concentrated hydrochloric acid. The suspension was concentrated under reduced pressure and then extracted with ethylacetate. The organic layer was dried over Na2SO4 and the solvent was removed under reduced pressure to yield a white solid.

Aufarbeitung

  1. temperatureThe solution was cooled to RT
  2. concentrationThe suspension was concentrated under reduced pressure
  3. extractionextracted with ethylacetate
  4. dry with materialThe organic layer was dried over Na2SO4
  5. customthe solvent was removed under reduced pressure
  6. customto yield a white solid

Quellen und Nachweise

ORD-Eintrag
ord-10463997ee3e4311bd06cde42f2b1e45
Quelldatensatz
uspto-grants-2006_06
Patentnummer
US07067665B2

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