Dimethyl Sulfoxide → HCID 69652303, compound

HRID 1831790Notes

Reaction equation

HRID 1831790 reaction equation
[CH3:1][O:2][C:3](=[O:23])[C:4]1[CH:9]=[CH:8][C:7]([C:10]#[N:11])=[C:6]([O:12][CH2:13][CH2:14][C:15]2[CH:20]=[CH:19][C:18]([Cl:21])=[CH:17][C:16]=2[Cl:22])[CH:5]=1.CS(C)=[O:26]>OO.C(OCC)(=O)C>[CH3:1][O:2][C:3](=[O:23])[C:4]1[CH:9]=[CH:8][C:7]([C:10]([NH2:11])=[O:26])=[C:6]([O:12][CH2:13][CH2:14][C:15]2[CH:20]=[CH:19][C:18]([Cl:21])=[CH:17][C:16]=2[Cl:22])[CH:5]=1

Participants

5

Reactant 2

HCID 679Dimethyl SulfoxideHCID 69652326HCID 69652326, compound

Product 1

HCID 69652303HCID 69652303, compound

Reagents, catalysts & solvents 2

HCID 784Hydrogen PeroxideSolventHCID 8857Ethyl AcetateSolvent

Procedure

To a solution of 100 mg 4-Cyano-3-[2-(2,4-dichloro-phenyl)-ethoxy]-benzoic acid methyl ester in 2 ml DMSO 93 mg K2CO3 and 68 μl H2O2 (35%) were added at RT. After stirring the reaction over night the mixture was taken up in 5 ml ethyl acetate and 3 ml water and filtered through a chem elut® cartridge by elution with ethyl acetate. After removal of the solvent the crude product was subjected to the subsequent reaction.

Workup

  1. customthe reaction over night the mixture
  2. filtration3 ml water and filtered through a chem elut® cartridge by elution with ethyl acetate
  3. customAfter removal of the solvent the crude product
  4. customwas subjected to the subsequent reaction

Sources & evidence

ORD record
ord-858eafe9c38749be8b152f0c8aa1a530
Source dataset
uspto-grants-2006_06
Patent number
US07067665B2

Reaction notes

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