Hydrochloric Acid → HCID 22052462, compound

HRID 1831798Notes

Reaction equation

HRID 1831798 reaction equation
Cl.[Cl:2][C:3]1[CH:8]=[C:7]([Cl:9])[CH:6]=[CH:5][C:4]=1[CH2:10][CH2:11][O:12][C:13]1[CH:14]=[C:15]([CH:26]=[CH:27][C:28]=1[O:29][CH3:30])[C:16]([NH:18][CH2:19][CH:20]1[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]1)=[O:17].[OH-].[Na+].Br[CH2:34][C:35]([OH:37])=[O:36].Cl>CCO.O>[Cl:2][C:3]1[CH:8]=[C:7]([Cl:9])[CH:6]=[CH:5][C:4]=1[CH2:10][CH2:11][O:12][C:13]1[CH:14]=[C:15]([CH:26]=[CH:27][C:28]=1[O:29][CH3:30])[C:16]([NH:18][CH2:19][CH:20]1[CH2:25][CH2:24][N:23]([CH2:34][C:35]([OH:37])=[O:36])[CH2:22][CH2:21]1)=[O:17]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 6227Bromoacetic AcidHCID 14798Sodium HydroxideHCID 22052413HCID 22052413, compound

Product 1

HCID 22052462HCID 22052462, compound

Reagents, catalysts & solvents 1

HCID 19096565Water ethanolSolvent

Procedure

To 1 g 3-[2-(2,4-Dichloro-phenyl)-ethoxy]-4-methoxy-N-piperidin-4-ylmethyl-benzamide hydrochloride and 400 mg NaOH in 50 ml EtOH/H2O 1:1 0.35 g bromo acetic acid were added at RT. After stirring over night the reaction mixture was acidified with half concentrated HCl. After evaporation of the solvent the residue was coevaporated with toluene. The waxy brown solid was subjected to the subsequent reaction without further purification.

Workup

  1. customAfter evaporation of the solvent the residue
  2. customThe waxy brown solid was subjected to the subsequent reaction without further purification

Sources & evidence

ORD record
ord-ebf0caef0ab44d8d8117e0c6a1c0b4e7
Source dataset
uspto-grants-2006_06
Patent number
US07067665B2

Reaction notes

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