Acetophenone → HCID 231770, compound

HRID 1831873Notes

Reaction equation

HRID 1831873 reaction equation
[OH-].[Na+].[CH3:3][C:4]([C:6]1[CH:11]=[CH:10][C:9]([Br:12])=[CH:8][CH:7]=1)=[O:5].[Br:13][C:14]1[CH:21]=[CH:20][C:17]([CH:18]=O)=[CH:16][CH:15]=1.C(C1C=CC=CC=1)(=O)C>O.C(O)C>[Br:13][C:14]1[CH:21]=[CH:20][C:17]([CH:18]=[CH:3][C:4]([C:6]2[CH:11]=[CH:10][C:9]([Br:12])=[CH:8][CH:7]=2)=[O:5])=[CH:16][CH:15]=1

Participants

7

Reactant 4

HCID 7410AcetophenoneHCID 7466p-BromoacetophenoneHCID 14798Sodium HydroxideHCID 707414-Bromobenzaldehyde

Product 1

HCID 231770HCID 231770, compoundYield 97%

Reagents, catalysts & solvents 2

HCID 702EthanolSolvent2×HCID 962WaterSolvent

Procedure

Sodium hydroxide (1.8 g, 45 mmol) and 4-bromoacetophenone (7.12 g, 36 mmol) were dissolved in water (18 mL) and ethanol (50 mL). 4-Bromo benzaldehyde (6.62 g, 36 mmol) dissolved in ethanol (20 mL) was added dropwise to the acetophenone solution. A slurry quickly formed, which was allowed to stir overnight. The slurry was filtered, was with water until the filtrate was neutral to pH paper, and dried at 100° C. for 12 hours. A light tan solid was obtained (12.8 g, 97% yield).

Workup

  1. customA slurry quickly formed
  2. filtrationThe slurry was filtered
  3. customdried at 100° C. for 12 hours
  4. customA light tan solid was obtained (12.8 g, 97% yield)

Sources & evidence

ORD record
ord-9c74855f81ac49e38c5d153ef3cdc736
Source dataset
uspto-grants-2006_06
Patent number
US07067702B2

Reaction notes

Loading…