Benzaldehyde → 1774-66-9

HRID 1831875Notes

Reaction equation

HRID 1831875 reaction equation
[OH-].[Na+].[CH3:3][C:4]([C:6]1[CH:11]=[CH:10][C:9]([Br:12])=[CH:8][CH:7]=1)=O.[CH:13](=[O:20])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.C(C1C=CC=CC=1)(=O)C>O.C(O)C>[Br:12][C:9]1[CH:10]=[CH:11][C:6]([CH:4]=[CH:3][C:13]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[O:20])=[CH:7][CH:8]=1

Participants

7

Reactant 4

HCID 240BenzaldehydeHCID 7410AcetophenoneHCID 7466p-BromoacetophenoneHCID 14798Sodium Hydroxide

Product 1

HCID 1021591774-66-9Yield 93%

Reagents, catalysts & solvents 2

HCID 702EthanolSolvent2×HCID 962WaterSolvent

Procedure

Sodium hydroxide (1.88 g, 47 mmol) and 4-bromoacetophenone (7.47 g, 37.5 mmol) were dissolved in water (15 mL) and ethanol (50 mL). Benzaldehyde (4.00 g, 37.5 mmol) dissolved in ethanol (20 mL) was added dropwise to the acetophenone solution. A slurry quickly formed, which was allowed to stir overnight. The slurry was filtered, was with water until the filtrate was neutral to pH paper, and dried at 100° C. for 12 hours. A light tan solid was obtained (10.0 g, 93% yield).

Workup

  1. customA slurry quickly formed
  2. filtrationThe slurry was filtered
  3. customdried at 100° C. for 12 hours
  4. customA light tan solid was obtained (10.0 g, 93% yield)

Sources & evidence

ORD record
ord-7e09a1cac851415bbf0883d7c87b03de
Source dataset
uspto-grants-2006_06
Patent number
US07067702B2

Reaction notes

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