4-Chlorophenol → 1-{[(2R)-3-Chloro-2-methylpropyl]oxy}-2-fluorobenzene

HRID 1832510Notes

Reaction equation

HRID 1832510 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[OH:8].Br[CH2:10][C@@H:11]([CH3:14])[CH2:12][Cl:13].ClC1C=CC(OC[C@@H](C)CCl)=CC=1.ClC1C=CC(O)=CC=1>>[Cl:13][CH2:12][C@H:11]([CH3:14])[CH2:10][O:8][C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[F:1]

Participants

5

Reactant 4

HCID 46844-ChlorophenolHCID 97072-FluorophenolHCID 5479122(2S)-1-bromo-3-chloro-2-methylpropane2×HCID 695243531-Chloro-4-{[(2R)-3-chloro-2-methylpropyl]oxy}benzene

Product 1

HCID 695238051-{[(2R)-3-Chloro-2-methylpropyl]oxy}-2-fluorobenzene

Procedure

Prepared by Procedure U and Scheme AK using 2-fluorophenol and (2S)-1-bromo-3-chloro-2-methylpropane. 1-CHLORO-4-{[(2R)-3-CHLORO-2-METHYLPROPYL]OXY}BENZENE: Prepared by Procedure U and Scheme AK using 4-chlorophenol and (2S)-1-bromo-3-chloro-2-methylpropane.

Workup

  1. customPrepared by Procedure U and Scheme AK

Sources & evidence

ORD record
ord-107997bf75d64579a764f2a7700212e9
Source dataset
uspto-grants-2006_06
Patent number
US07067534B1

Reaction notes

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