HRID1832664

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2879

p-Cresol

C7H8O

HCID24905

1H-Indole, 5-bromo-

C8H6BrN

HCID16757255

2-methyl-N-[3-(4-piperidyl)phenyl]propanamide

C15H22N2O

HCID22048835

未命名化合物

HCID22049000

未命名化合物

PRODUCTS

生成物

结构：CC(C)C(=O)Nc1cccc(C2CCN(Cc3c[nH]c4cc(-c5ccccc5F)ccc34)CC2)c1

HCID22049533

未命名化合物

PROCEDURE

实验过程

Prepared by Procedure D and Scheme N using 6-(2-fluorophenyl)-1H-indole and 2-methyl-N-[3-(4-piperidinyl)phenyl]propanamide: ESMS m/e: 470.2 (M+H)+. 5-(4-METHYLPHENOXY)-1H-INDOLE: Prepared by Procedure J and Scheme U using 5-bromo-1H-indole and p-cresol: ESMS m/e: 224.0 (M+H)+.

WORKUP

后处理

customPrepared by Procedure D and Scheme N

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-8a8683c01f6441be89a48b3121cda0e8
来源数据集: uspto-grants-2006_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07067534B1
来源说明: uspto-grants-2006_06

反应 SMILES

[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[CH:16]=[C:15]2[C:11]([CH:12]=[CH:13][NH:14]2)=[CH:10][CH:9]=1.[CH3:17][CH:18]([CH3:34])[C:19]([NH:21][C:22]1[CH:27]=[CH:26][CH:25]=[C:24]([CH:28]2[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]2)[CH:23]=1)=[O:20].[CH3:35]C1C=CC(OC2C=C3C(=CC=2)NC=C3)=CC=1.BrC1C=C2C(=CC=1)NC=C2.C1C(O)=CC=C(C)C=1>>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[CH:16]=[C:15]2[C:11]([C:12]([CH2:35][N:31]3[CH2:32][CH2:33][CH:28]([C:24]4[CH:23]=[C:22]([NH:21][C:19](=[O:20])[CH:18]([CH3:34])[CH3:17])[CH:27]=[CH:26][CH:25]=4)[CH2:29][CH2:30]3)=[CH:13][NH:14]2)=[CH:10][CH:9]=1