P-Cresol → N-[3-(1-{[6-(2-Fluorophenyl)-1H-indol-3-YL]methyl}-4-piperidinyl)phenyl]-2-methylpropanamide

HRID 1832664Notes

Reaction equation

HRID 1832664 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[CH:16]=[C:15]2[C:11]([CH:12]=[CH:13][NH:14]2)=[CH:10][CH:9]=1.[CH3:17][CH:18]([CH3:34])[C:19]([NH:21][C:22]1[CH:27]=[CH:26][CH:25]=[C:24]([CH:28]2[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]2)[CH:23]=1)=[O:20].[CH3:35]C1C=CC(OC2C=C3C(=CC=2)NC=C3)=CC=1.BrC1C=C2C(=CC=1)NC=C2.C1C(O)=CC=C(C)C=1>>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[CH:16]=[C:15]2[C:11]([C:12]([CH2:35][N:31]3[CH2:32][CH2:33][CH:28]([C:24]4[CH:23]=[C:22]([NH:21][C:19](=[O:20])[CH:18]([CH3:34])[CH3:17])[CH:27]=[CH:26][CH:25]=4)[CH2:29][CH2:30]3)=[CH:13][NH:14]2)=[CH:10][CH:9]=1

Participants

6

Reactant 5

HCID 2879P-CresolHCID 249055-BromoindoleHCID 167572552-methyl-N-[3-(4-piperidyl)phenyl]propanamideHCID 220488355-(4-methylphenoxy)-1H-indoleHCID 220490006-(2-fluorophenyl)-1H-indole

Product 1

HCID 22049533N-[3-(1-{[6-(2-Fluorophenyl)-1H-indol-3-YL]methyl}-4-piperidinyl)phenyl]-2-methylpropanamide

Procedure

Prepared by Procedure D and Scheme N using 6-(2-fluorophenyl)-1H-indole and 2-methyl-N-[3-(4-piperidinyl)phenyl]propanamide: ESMS m/e: 470.2 (M+H)+. 5-(4-METHYLPHENOXY)-1H-INDOLE: Prepared by Procedure J and Scheme U using 5-bromo-1H-indole and p-cresol: ESMS m/e: 224.0 (M+H)+.

Workup

  1. customPrepared by Procedure D and Scheme N

Sources & evidence

ORD record
ord-8a8683c01f6441be89a48b3121cda0e8
Source dataset
uspto-grants-2006_06
Patent number
US07067534B1

Reaction notes

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