N-(3-[1-(2-aminoethyl)-4-piperidinyl]phenyl)-2-methylpropanamide → 5-(3,5-Dichlorophenoxy)-N-(2-{4-[3-(isobutyrylamino)phenyl]-1-piperidinyl}ethyl)-3-furamide

HRID 1832810Notes

Reaction equation

HRID 1832810 reaction equation
[NH2:1][CH2:2][CH2:3][N:4]1[CH2:9][CH2:8][CH:7]([C:10]2[CH:11]=[C:12]([NH:16][C:17](=[O:21])[CH:18]([CH3:20])[CH3:19])[CH:13]=[CH:14][CH:15]=2)[CH2:6][CH2:5]1.[Cl:22][C:23]1[CH:24]=[C:25]([CH:35]=[C:36]([Cl:38])[CH:37]=1)[O:26][C:27]1[O:31][CH:30]=[C:29]([C:32](Cl)=[O:33])[CH:28]=1>C1COCC1>[Cl:22][C:23]1[CH:24]=[C:25]([CH:35]=[C:36]([Cl:38])[CH:37]=1)[O:26][C:27]1[O:31][CH:30]=[C:29]([C:32]([NH:1][CH2:2][CH2:3][N:4]2[CH2:9][CH2:8][CH:7]([C:10]3[CH:15]=[CH:14][CH:13]=[C:12]([NH:16][C:17](=[O:21])[CH:18]([CH3:19])[CH3:20])[CH:11]=3)[CH2:6][CH2:5]2)=[O:33])[CH:28]=1

Participants

4

Reactant 2

HCID 16757469N-(3-[1-(2-aminoethyl)-4-piperidinyl]phenyl)-2-methylpropanamideHCID 220485985-(3,5-Dichlorophenoxy)-3-furoyl chloride

Product 1

HCID 220493625-(3,5-Dichlorophenoxy)-N-(2-{4-[3-(isobutyrylamino)phenyl]-1-piperidinyl}ethyl)-3-furamide

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Prepared by Procedure Q1 (THF) and Scheme AT using N-{3-[1-(2-aminoethyl)-4-piperidinyl]phenyl}-2-methylpropanamide and 5-(3,5-dichlorophenoxy)-3-furoyl chloride: ESMS m/e: 544.1 (M+H)+.

Sources & evidence

ORD record
ord-468b9c026cb8492193899d3eba44f111
Source dataset
uspto-grants-2006_06
Patent number
US07067534B1

Reaction notes

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