2,2-Diphenylacetyl chloride → N-[3-(1-{2-[(Diphenylacetyl)amino]ethyl}-4-piperidinyl)phenyl]-2-methylpropanamide

HRID 1832811Notes

Reaction equation

HRID 1832811 reaction equation
[NH2:1][CH2:2][CH2:3][N:4]1[CH2:9][CH2:8][CH:7]([C:10]2[CH:11]=[C:12]([NH:16][C:17](=[O:21])[CH:18]([CH3:20])[CH3:19])[CH:13]=[CH:14][CH:15]=2)[CH2:6][CH2:5]1.[C:22]1([CH:28]([C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)[C:29](Cl)=[O:30])[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1>C1COCC1>[C:32]1([CH:28]([C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=2)[C:29]([NH:1][CH2:2][CH2:3][N:4]2[CH2:9][CH2:8][CH:7]([C:10]3[CH:11]=[C:12]([NH:16][C:17](=[O:21])[CH:18]([CH3:19])[CH3:20])[CH:13]=[CH:14][CH:15]=3)[CH2:6][CH2:5]2)=[O:30])[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=1

Participants

4

Reactant 2

HCID 746372,2-Diphenylacetyl chlorideHCID 16757469N-(3-[1-(2-aminoethyl)-4-piperidinyl]phenyl)-2-methylpropanamide

Product 1

HCID 16755870N-[3-(1-{2-[(Diphenylacetyl)amino]ethyl}-4-piperidinyl)phenyl]-2-methylpropanamide

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Prepared by Procedure Q1 (THF) and Scheme AT using N-{3-[1-(2-aminoethyl)-4-piperidinyl]phenyl}-2-methylpropanamide and diphenylacetyl chloride: ESMS m/e: 484.2 (M+H)+.

Sources & evidence

ORD record
ord-d0dba251e9a849f597983e1922e30363
Source dataset
uspto-grants-2006_06
Patent number
US07067534B1

Reaction notes

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