反应详情

The above 1-(3-isopropoxybenzyl)-6,7-dimethoxyisoquinoline-4-carboxylic acid ethyl ester (2.20 g, 5.38 mmol) was dissolved into 100 ml of ethyl acetate. Then selenium dioxide (1.08 g, 9.73 mmol) was added and the mixture was refluxed for 30 minutes. The reaction mixture was filtered through a thin layer of silica gel. The filtrate was concentrated and then purified through a flash column chromatography using hexane and ethyl acetate (2.5/1 ratio) to give 1-(3-isopropoxybenzoyl)-6,7-dimethoxyisoquinoline-4-carboxylic acid ethyl ester as a solid (1.50 g, 66%).

1. temperaturethe mixture was refluxed for 30 minutes
2. filtrationThe reaction mixture was filtered through a thin layer of silica gel
3. concentrationThe filtrate was concentrated
4. custompurified through a flash column chromatography