Water → HCID 22048236, compound

To N,N-dimethylformamide (0.36 mL) at 0° C. was added phosphorous oxychloride (0.84 mL, 0.80 g, 10.9 mmol.) dropwise. The mixture was warmed to room temperature and stirred×30 minutes. The mixture was recooled in an ice-bath, and 7-benzyloxy-6-methoxy-1-(3-methoxy-benzyl)-1H-isoquinoline-2-carboxylic acid ethyl ester (2.15 g, 2.11 mmol) in N,N-dimethylformamide (5 mL) was added dropwise. After addition was complete, the mixture was heated on an oil bath×2 hours at 60° C. The mixture was cooled, poured into water (50 mL) and extracted with ethyl acetate (3×20 mL). The combined organic extracts were washed with water (3×20 mL), saturated aqueous sodium chloride solution (1×20 mL) and dried over anhydrous magnesium sulfate. Concentration of the solvent in vacuo gave a viscous oil that was dissolved methanol (20 mL), and a solution of powdered potassium hydroxide (0.63 g, 10.5 mmol) in methanol (5 mL) was added dropwise. The mixture was stirred overnight (14 hours) at room temperature. The mixture was poured into water (100 mL) and extracted with diethyl ether (3×30 mL). The combined organic extracts were washed with water (30 mL), saturated aqueous sodium chloride solution (30 mL) and dried over anhydrous magnesium sulfate. Concentration gave an orange foam that was dissolved in dichloromethane (100 mL), and maganese (IV) oxide (3 g, 34.8 mmol.) was added in one portion. The mixture was stirred at room temperature×2 hours. Silica gel (5 g) was added to the mixture. The mixture was filtered through a silica gel pad. The silica gel pad was washed with 50% ethyl acetate in hexanes (200 mL). Concentration of the combined filtrates and precipitation from ethyl acetate with hexanes gave 7-benzyloxy-6-methoxy-1-(3-methoxy-benzyl)-isoquinoline-4-carbaldehyde (1.00 g, 2.42 mmol, 53%) as a yellow solid.

1. customThe mixture was recooled in an ice-bath
2. additionAfter addition
3. temperaturethe mixture was heated on an oil bath×2 hours at 60° C
4. temperatureThe mixture was cooled
5. extractionextracted with ethyl acetate (3×20 mL)
6. washThe combined organic extracts were washed with water (3×20 mL), saturated aqueous sodium chloride solution (1×20 mL)
7. dry with materialdried over anhydrous magnesium sulfate
8. customConcentration of the solvent in vacuo gave a viscous oil that
9. stirringThe mixture was stirred overnight (14 hours) at room temperature
10. extractionextracted with diethyl ether (3×30 mL)
11. washThe combined organic extracts were washed with water (30 mL), saturated aqueous sodium chloride solution (30 mL)
12. dry with materialdried over anhydrous magnesium sulfate
13. concentrationConcentration
14. customgave an orange foam that
15. stirringThe mixture was stirred at room temperature×2 hours
16. additionSilica gel (5 g) was added to the mixture
17. filtrationThe mixture was filtered through a silica gel pad
18. washThe silica gel pad was washed with 50% ethyl acetate in hexanes (200 mL)
19. customConcentration of the combined filtrates and precipitation from ethyl acetate with hexanes

ORD record

ord-34eeffa6c3174a94a051168a352cd588

Source dataset

uspto-grants-2006_06

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07067529B2