反应详情

To a stirred solution of 3,4-dimethoxyphenyl acetonitrile (8.86 g, 50 mmol) in diethyl ether (150 mL) was added sodium methoxide (2.97 g, 55 mmol) and ethyl formate (4.04 mL, 50 mmol) in diethyl ether (50 mL) solution. The reaction mixture was stirred at room temperature for 24 hrs. A solid was precipitated. The mixture was filtered and the solid was collected and washed with diethyl ether. The solid was dissolved in water (50 mL). 10% acetic acid was then added dropwise to the solution. A white precipitation was formed and the mixture was filtered again. The while solid was washed with water and collected to afford 2-(3,4-dimethoxy-phenyl)-3-oxo-propionitrile (8.0 g, 78% yield).

1. customA solid was precipitated
2. filtrationThe mixture was filtered
3. customthe solid was collected
4. washwashed with diethyl ether
5. dissolutionThe solid was dissolved in water (50 mL)
6. addition10% acetic acid was then added dropwise to the solution
7. customA white precipitation
8. customwas formed
9. filtrationthe mixture was filtered again
10. washThe while solid was washed with water
11. customcollected