O-Methylisourea → HCID 53677251, compound

HRID 1833285Notes

Reaction equation

HRID 1833285 reaction equation
[CH3:1][O:2][C:3]([NH2:5])=[NH:4].C[O:7][C:8]([P:10](=[O:15])([O:13][CH3:14])[O:11][CH3:12])=O>O1CCCC1>[NH2:4][C:3](=[N:5][C:8]([P:10](=[O:15])([O:13][CH3:14])[O:11][CH3:12])=[O:7])[O:2][CH3:1]

Participants

4

Reactant 2

HCID 75544O-MethylisoureaHCID 451443Trimethyl phosphonoformate

Product 1

HCID 53677251HCID 53677251, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

a mixture of 23 parts of 0-methylisourea and 54 parts of dimethyl methoxycarbonylphosphonate in 1000 parts of anhydrous tetrahydrofuran was refluxed for one hour. The solvent was removed to give dimethyl 1-amino-1-methoxy-methyleneaminocarbonylphosphonate, nD27 = 1.4774.

Workup

  1. temperaturewas refluxed for one hour
  2. customThe solvent was removed

Sources & evidence

ORD record
ord-a39fd5c9341d4daa89d39a40ac6c940a
Source dataset
uspto-grants-1978_01
Patent number
US04066434

Reaction notes

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