Ethanol → 5-Ethoxy-2-methylpyrazolo[1,5-a]pyrido[3,4-e]pyrimidine

HRID 1833343Notes

Reaction equation

HRID 1833343 reaction equation
Cl[C:2]1[C:7]2[CH:8]=[N:9][CH:10]=[CH:11][C:6]=2[N:5]2[N:12]=[C:13]([CH3:15])[CH:14]=[C:4]2[N:3]=1.[Na].[CH2:17]([OH:19])[CH3:18]>O>[CH2:17]([O:19][C:2]1[C:7]2[CH:8]=[N:9][CH:10]=[CH:11][C:6]=2[N:5]2[N:12]=[C:13]([CH3:15])[CH:14]=[C:4]2[N:3]=1)[CH3:18]

Participants

5

Reactant 3

HCID 702EthanolHCID 5360545SodiumHCID 213891855-Chloro-2-methylpyrazolo[1,5-a]pyrido[3,4-e]pyrimidine

Product 1

HCID 213891755-Ethoxy-2-methylpyrazolo[1,5-a]pyrido[3,4-e]pyrimidine

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

2.2 g. of 5-chloro-2-methylpyrazolo[1,5-a]pyrido[3,4-e]pyrimidine are added to a solution of 0.5 g. of sodium in 30 ml. of ethanol. The solution is refluxed with stirring for 12 hours. 10 ml. of water are added and the crystalline 5-ethoxy-2-methylpyrazolo[1,5-a]pyrido[3,4-e]pyrimidine is filtered off, yield: 1.4 g. (61%); m.p. 156.2° (methanol).

Workup

  1. temperatureThe solution is refluxed
  2. filtrationthe crystalline 5-ethoxy-2-methylpyrazolo[1,5-a]pyrido[3,4-e]pyrimidine is filtered off

Sources & evidence

ORD record
ord-0d9d9bffcc0f401e8a1d1b162124b44d
Source dataset
uspto-grants-1978_01
Patent number
US04066645

Reaction notes

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