Iodoethane → HCID 21389234, compound

HRID 1833368Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[O:14][C:13]3[C:12](=[O:15])[C:11]([C:16]([O:18][CH2:19][CH3:20])=[O:17])=[CH:10][NH:9][C:8]=3[C:7](=[O:21])[C:6]=2[CH:22]=1.[CH2:23](I)[CH3:24]>>[CH2:23]([N:9]1[CH:10]=[C:11]([C:16]([O:18][CH2:19][CH3:20])=[O:17])[C:12](=[O:15])[C:13]2[O:14][C:5]3[CH:4]=[CH:3][C:2]([Cl:1])=[CH:22][C:6]=3[C:7](=[O:21])[C:8]1=2)[CH3:24]

Participants

Reactant 2

HCID 6340Iodoethane

HCID 12736922HCID 12736922, compound

Product 1

HCID 21389234HCID 21389234, compoundYield 78%

Procedure

Prepared from ethyl 8-chloro-4,10-dihydro-4,10-dioxo-1H-1-benzopyrano[3,2-b]pyridine-3-carboxylate (3.19 g, 0.01 mole) and ethyl iodide (6.24 g, 0.04 mole) by the method described for Example 9. Recrystallization from DMF gave white crystals (2.7 g, 78%), m.p. 257°-259°.

Workup

customRecrystallization from DMF

Sources & evidence

ORD record: ord-3a54694e8e3a434bb85bc8a40b443246
Source dataset: uspto-grants-1978_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04066655

Reaction notes

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