Butyl iodide → HCID 21389230, compound

HRID 1833369Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[O:14][C:13]3[C:12](=[O:15])[C:11]([C:16]([O:18][CH2:19][CH3:20])=[O:17])=[CH:10][NH:9][C:8]=3[C:7](=[O:21])[C:6]=2[CH:22]=1.[CH2:23](I)[CH2:24][CH2:25][CH3:26]>>[CH2:23]([N:9]1[CH:10]=[C:11]([C:16]([O:18][CH2:19][CH3:20])=[O:17])[C:12](=[O:15])[C:13]2[O:14][C:5]3[CH:4]=[CH:3][C:2]([Cl:1])=[CH:22][C:6]=3[C:7](=[O:21])[C:8]1=2)[CH2:24][CH2:25][CH3:26]

Participants

Reactant 2

HCID 10962Butyl iodide

HCID 12736922HCID 12736922, compound

Product 1

HCID 21389230HCID 21389230, compoundYield 95.1%

Procedure

Prepared from ethyl 8-chloro-4,10-dihydro-4,10-dioxo-1H-1-benzopyrano[3,2-b]pyridine-3-carboxylate (3.195 g, 0.01 mole) and butyl iodide (7.36 g, 0.04 mole) by the method described for Example 9. Recrystallization from methanol gave white crystals (3.575 g, 95%), m.p. 226°-228°.

Workup

customRecrystallization from methanol

Sources & evidence

ORD record: ord-5fd7f8b4f92a4bfc84e6787acab5a6ac
Source dataset: uspto-grants-1978_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04066655

Reaction notes

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