Phosphorus oxychloride → 2-(4-Pentylphenyl)pyrimidine-5-carbonitrile

HRID 1833726Notes

Reaction equation

HRID 1833726 reaction equation
[CH2:1]([C:6]1[CH:11]=[CH:10][C:9]([C:12]2[N:17]=[CH:16][C:15]([C:18]([NH2:20])=O)=[CH:14][N:13]=2)=[CH:8][CH:7]=1)[CH2:2][CH2:3][CH2:4][CH3:5].P(Cl)(Cl)(Cl)=O>>[C:18]([C:15]1[CH:14]=[N:13][C:12]([C:9]2[CH:10]=[CH:11][C:6]([CH2:1][CH2:2][CH2:3][CH2:4][CH3:5])=[CH:7][CH:8]=2)=[N:17][CH:16]=1)#[N:20]

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 21388835HCID 21388835, compound

Product 1

HCID 135748242-(4-Pentylphenyl)pyrimidine-5-carbonitrile

Procedure

9.1 G. of 2-(p-n-pentylphenyl)-5-pyrimidinecarboxamide are reacted with 100 ml. of phosphorus oxychloride with the exclusion of moisture, worked up and purified in a manner analogous to that described in Example 7. The pure, colorless 5-cyano-2-(4-n-pentylphenyl)-pyrimidine has a melting point of 96.0°-96.2° C. and a clearing point of 109.0° C.

Workup

  1. custompurified in a manner analogous to
  2. customa clearing point of 109.0° C.

Sources & evidence

ORD record
ord-183323771c6e4712b21ab48d57d0c34a
Source dataset
uspto-grants-1978_01
Patent number
US04066570

Reaction notes

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