反应详情

The starting material can be obtained according to the procedure of A. R. Todd and F. Bergel, J. Chem. Soc. 1937, 365 by reaction of p-n-propylbenzamidine hydrochloride with α-ethoxymethylene- α-cyanoacetic acid ethyl ester and sodium ethylate in ethanol and then with sodium hydroxide solution. The resulting 5-cyano-4-hydroxy-2-(4-n-propylphenyl)-pyrimidine (melting point 246.0°-247.6° C) is treated with phosphorus oxychloride to give 4-chloro-5-cyano-2-(4-n-propylphenyl)-pyrimidine having a melting point of 109.4°-109.7° C.

1. customThe starting material can be obtained