Triethylamine → HCID 12526285, compound

HRID 1833816Notes

Reaction equation

HRID 1833816 reaction equation
C(N(CC)CC)C.[CH3:8][N:9]=[C:10]=[O:11].[OH:12][C:13]1[N:17]=[C:16]([S:18][CH2:19][CH:20]=[CH2:21])[S:15][N:14]=1>O1CCCC1>[CH3:8][NH:9][C:10]([N:14]1[C:13](=[O:12])[N:17]=[C:16]([S:18][CH2:19][CH:20]=[CH2:21])[S:15]1)=[O:11]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 12228Methyl IsocyanateHCID 178460815HCID 178460815, compound

Product 1

HCID 12526285HCID 12526285, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
20 °C

Procedure

0.5 ml of triethylamine and 5 ml of methyl isocyanate were added to a solution of 13.9 g of 3-hydroxy-5-allylthio-1,2,4-thiadiazole in 150 ml of tetrahydrofuran and the mixture was stirred at 20° C for 2 hours and was concentrated to dryness under reduced pressure. The residue was empasted with ethyl ether and was vacuum filtered and dried to obtain 15.9 g of 2-(N-methylcarbamoyl)-5-allylthio-1,2,4-thiadiazole-3-one melting at 110° C.

Workup

  1. concentrationwas concentrated to dryness under reduced pressure
  2. filtrationfiltered
  3. customdried

Sources & evidence

ORD record
ord-da390a74f497449495b39c641b55f716
Source dataset
uspto-grants-1978_01
Patent number
US04067720

Reaction notes

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