HCID 21388034, compound → HCID 21388032, compound

HRID 1833876Notes

Reaction equation

HRID 1833876 reaction equation
[C:1]([N:5]1[CH2:9][CH:8]([CH2:10][O:11][C:12]2[C:21]3[C:16](=[CH:17][CH:18]=[C:19]([Cl:22])[CH:20]=3)[C:15]([CH3:23])=[CH:14][N:13]=2)[O:7]C1C1C=CC=CC=1)([CH3:4])([CH3:3])[CH3:2]>Cl>[OH:7][CH:8]([CH2:9][NH:5][C:1]([CH3:4])([CH3:3])[CH3:2])[CH2:10][O:11][C:12]1[C:21]2[C:16](=[CH:17][CH:18]=[C:19]([Cl:22])[CH:20]=2)[C:15]([CH3:23])=[CH:14][N:13]=1

Participants

3

Reactant 1

HCID 21388034HCID 21388034, compound

Product 1

HCID 21388032HCID 21388032, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

1 g of 1-(3-tert.-Butyl-2-phenyl-5-oxazolidinyl-methoxy)-7-chloro-4-methylisoquinoline is heated to 80° in 10 ml of 1N hydrochloric acid for 10 minutes. The reaction mixture is extracted with ether. The ethereal phase is discarded and the aqueous phase worked up to yield the title compound in free base form. M.p. 116°-117°.

Workup

  1. extractionThe reaction mixture is extracted with ether

Sources & evidence

ORD record
ord-745197a7ef254b54a06f2dcd24e6ae9a
Source dataset
uspto-grants-1978_01
Patent number
US04067873

Reaction notes

Loading…