Water → HCID 21387984, Verbindung

HRID 1833879Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1833879
[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][C:7]([Cl:11])=[CH:8][CH:9]=2)[C:4]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[C:3]1[NH:18][C:19]([O:21][CH2:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)=[O:20].[OH2:29].N.[OH2:31]>C(O)(=O)C>[Cl:11][C:7]1[CH:8]=[CH:9][C:10]([N:2]([CH3:1])[C:3](=[O:29])[NH:18][C:19]([O:21][CH2:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)=[O:20])=[C:5]([C:4](=[O:31])[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH:6]=1

Komponenten

5

Edukt 3

HCID 962Water2×HCID 12896473Azane;hydrateHCID 21387986HCID 21387986, Verbindung

Produkt 1

HCID 21387984HCID 21387984, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

To a suspension of 1.0 g of benzyl 1-methyl-3-phenyl-5-chloroindole-2-carbamate in 10 ml of acetic acid, a solution of 1.0 g of chromic anhydride in 1 ml of water was added dropwise with stirring below 25° C. The resulting mixture was stirred at room temperature for 6 hours, and then 25 ml of water was added to the reaction mixture. The resulting reaction mixture was neutralized with concentrated ammonia water and extracted with ether. The extracted ether layer was washed with water and dried over Glauber's salt. The solvent was removed by distillation under reduced pressure to give 0.94 g of oily benzyl 4-(4-chloro-2-benzoylphenyl)-4-methylallophanate. After dissolving the oily material in 9 ml of ethanol and adding 3 ml of concentrated hydrochloric acid thereto, the resulting mixture was refluxed for 1 hour. After removing the solvent by distillation under reduced pressure, the obtained residue was neutralized with concentrated ammonia water. The obtained crystals were collected by filtration, washed with water and recrystallized from ethanol to give 1-methyl-4-phenyl-6-chloro-2(1H)-quinazolinone having a melting point of 220° - 221° C.

Aufarbeitung

  1. stirringThe resulting mixture was stirred at room temperature for 6 hours
  2. customThe resulting reaction mixture
  3. extractionextracted with ether
  4. washThe extracted ether layer was washed with water
  5. dry with materialdried over Glauber's salt
  6. customThe solvent was removed by distillation under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-3a477ee6973e492183e71013d2067562
Quelldatensatz
uspto-grants-1978_01
Patentnummer
US04067868

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