Benzene → 1-[Ethoxy(isothiocyanato)phosphoryl]oxyethane
Reaction equation
[CH2:1]([O:3][P:4](Cl)([O:6][CH2:7][CH3:8])=[O:5])[CH3:2].[S-:10][C:11]#[N:12].[NH4+].C1C=CC=CC=1.C1(C)C=CC=CC=1>C1(C)C(C)=CC=CC=1>[CH2:1]([O:3][P:4]([N:12]=[C:11]=[S:10])([O:6][CH2:7][CH3:8])=[O:5])[CH3:2]Participants
6
Reactant 4
Product 1
Reagents, catalysts & solvents 1
Procedure
One molar equivalent of diethoxyphosphoryl chloride is reacted with a 1.1 to 1.2 molar equivalent of ammonium thiocyanate in the presence of an inert solvent, such as benzene, toluene, xylene or the like, at about 20° C to 30° C for a period of time of about 24 hours. The so obtained solution of diethoxyphosphinyl isothiocyanate of formula (III) is washed several times with water and dilute sodium bicarbonate solution, and then the isothiocyanate is isolated by removing the solvent in vacuo. This reaction step may be graphically illustrated as follows: ##STR2##
Sources & evidence
- ORD record
- ord-2b7cc4e0a7514984ad4d059e2f815380
- Source dataset
- uspto-grants-1978_01
- Patent number
- US04067882
Reaction notes
Loading…