Formaldehyde → 2-Nitro-1-butanol

HRID 1833907Notes

Reaction equation

HRID 1833907 reaction equation
[N+:1]([CH2:4][CH2:5][CH3:6])([O-:3])=[O:2].[CH2:7]=[O:8]>>[NH2:1][CH:4]([CH2:5][CH3:6])[CH2:7][OH:8].[N+:1]([CH:4]([CH2:5][CH3:6])[CH2:7][OH:8])([O-:3])=[O:2]

Participants

4

Reactant 2

HCID 712FormaldehydeHCID 79031-Nitropropane

Product 2

HCID 118642-Nitro-1-butanolHCID 221292-Amino-1-butanol

Procedure

2-Amino-n-butanol is prepared by condensing 1-nitropropane with formaldehyde in an aqueous medium in the presence of a phase transfer agent which acts both as a basic catalyst and as a surfactant, and the resulting 2-nitro-n-butanol obtained is subjected to catalytic hydrogenation using a hydrogenating mixture consisting of hydrogen and nitrogen at a pressure of 8 to 12 bars.

Sources & evidence

ORD record
ord-30c414c30cef4d2ab6981927c2a833a5
Source dataset
uspto-grants-1978_01
Patent number
US04067905

Reaction notes

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