2-Aminothiazole → HCID 20557988, compound

HRID 1834291Notes

Reaction equation

[NH2:1][CH2:2][CH2:3][CH2:4][NH:5][C:6]1[S:7][CH:8]=[CH:9][N:10]=1.[NH2:11][C:12]1[S:13]C=CN=1.C(N=C=S)(=O)C1C=CC=CC=1>>[S:7]1[CH:8]=[CH:9][N:10]=[C:6]1[NH:5][CH2:4][CH2:3][CH2:2][NH:1][C:12]([NH2:11])=[S:13]

Participants

Reactant 3

HCID 21552-Aminothiazole

HCID 68284Benzoyl isothiocyanate

HCID 205580022-(3-Aminopropylamino)thiazole

Product 1

HCID 20557988HCID 20557988, compound

Procedure

By the procedure of Example 46, reacting 2-(3-aminopropylamino)thiazole (prepared from 2-aminothiazole by the method of Example 53) with benzoyl isothiocyanate gives N-benzoyl-N'-[(3-(2-thiazolylamino)propyl]thiourea. Removing the benzoyl group by the procedure of Example 46 gives N-[3-(2-thiazolylamino)propyl]thiourea.

Sources & evidence

ORD record: ord-beefd2f6d4b642a097588452f1a930e4
Source dataset: uspto-grants-1978_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04069327

Reaction notes

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