Potassium Acetate → HCID 20373037, compound

HRID 1834382Notes

Reaction equation

HRID 1834382 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]3[C:12](=[O:15])[N:13]=[N:14][C:10]3=[CH:9][C:8](=[O:16])[N:7]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[C:6]=2[CH:23]=1.[C:24]([O-])(=O)[CH3:25].[K+]>BrC1C=CC=CC=1.C(Cl)Cl.[Cu]>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]3[C:12](=[O:15])[N:13]([C:25]4[CH:24]=[CH:6][CH:23]=[CH:2][CH:3]=4)[NH:14][C:10]3=[CH:9][C:8](=[O:16])[N:7]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[C:6]=2[CH:23]=1

Participants

6

Reactant 2

HCID 517044Potassium AcetateHCID 20373035HCID 20373035, compound

Product 1

HCID 20373037HCID 20373037, compound

Reagents, catalysts & solvents 3

HCID 23978CopperCatalystHCID 6344DichloromethaneSolventHCID 7961BromobenzeneSolvent

Procedure

A mixture of 8.2 g of 8-chloro-6-phenyl-1H-s-triazolo[4,3-a][1,5]benzodiazepine-1,5-dione, 5 g of copper powder and 2.5 g of potassium acetate in 100 ml of bromobenzene are refluxed for 6 hours with stirring. The reaction is diluted with methylene chloride, filtered through a short Florisil column and the filtrate washed with dilute aqueous ammonium hydroxide. The organic phase is washed with water, dried and the solvent evaporated to give the title compound.

Workup

  1. temperatureare refluxed for 6 hours
  2. filtrationfiltered through a short Florisil column
  3. washthe filtrate washed with dilute aqueous ammonium hydroxide
  4. washThe organic phase is washed with water
  5. customdried
  6. customthe solvent evaporated

Sources & evidence

ORD record
ord-b233539d2fd84dfb901e7aab58aca5dc
Source dataset
uspto-grants-1978_01
Patent number
US04070355

Reaction notes

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