反应详情

A mixture of 8.2 g of 8-chloro-6-phenyl-1H-s-triazolo[4,3-a][1,5]benzodiazepine-1,5-dione, 5 g of copper powder and 2.5 g of potassium acetate in 100 ml of bromobenzene are refluxed for 6 hours with stirring. The reaction is diluted with methylene chloride, filtered through a short Florisil column and the filtrate washed with dilute aqueous ammonium hydroxide. The organic phase is washed with water, dried and the solvent evaporated to give the title compound.

1. temperatureare refluxed for 6 hours
2. filtrationfiltered through a short Florisil column
3. washthe filtrate washed with dilute aqueous ammonium hydroxide
4. washThe organic phase is washed with water
5. customdried
6. customthe solvent evaporated