Diethyl chlorophosphate → 1-[Ethoxy(isothiocyanato)phosphoryl]oxyethane
Reaction equation
[CH2:1]([O:3][P:4](Cl)([O:6][CH2:7][CH3:8])=[O:5])[CH3:2].[Na].[K].[S-:12][C:13]#[N:14].[NH4+]>>[CH2:1]([O:3][P:4]([N:14]=[C:13]=[S:12])([O:6][CH2:7][CH3:8])=[O:5])[CH3:2]Participants
5
Procedure
One molar equivalent of diethoxyphosphoryl chloride of formula (II) above is reacted neat with a 1.0 to 1.2 molar equivalent of sodium, potassium or ammonium thiocyanate at a temperature range of 5° C to 30° C and, preferably, 15° C to 25° C for a period of time from 2 to 4 hours to yield diethoxyphosphinyl isothiocyanate of formula (III), above. The reaction is slightly exothermic, easily controlled by a cooling bath.
Sources & evidence
- ORD record
- ord-4984d4ec430b4121827fa3544a120bdc
- Source dataset
- uspto-grants-1978_01
- Patent number
- US04070372
Reaction notes
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