Water → HCID 20373132, compound

HRID 1834425Notes

Reaction equation

HRID 1834425 reaction equation
[CH3:1][C:2]1[NH:3][CH:4]=[CH:5][C:6]=1[C:7]([O:9][CH2:10][CH3:11])=[O:8].[CH3:12][CH:13]1OC(C)OC(C)O1.O.[C:22](OC(=O)C)(=O)[CH3:23]>I.[PH2](O)=O>[CH3:1][C:2]1[NH:3][C:4]([CH2:22][CH3:23])=[C:5]([CH2:12][CH3:13])[C:6]=1[C:7]([O:9][CH2:10][CH3:11])=[O:8]

Participants

7

Reactant 4

HCID 962WaterHCID 7918Acetic AnhydrideHCID 31264ParaldehydeHCID 136747Ethyl 2-methyl-3-pyrrolecarboxylate

Product 1

HCID 20373132HCID 20373132, compound

Reagents, catalysts & solvents 2

HCID 24841Hydrogen iodideSolventHCID 4124402Phosphinic AcidSolvent

Procedure

A solution of 612 mg of 2-methyl-3-carbethoxy-pyrrole in 10 ml of hydriodic acid, 10 ml of acetic anhydride and 2 ml of hypophosphorous acid was stirred while 0.35 ml of paraldehyde was dropped in. Stirring was contined for 1/2 h and the solution was then poured into water. For analysis, the pale yellow micro crystals which separated (0.45 g, 53%, m.p. 104°-106°) were recrystallized from aqueous ethanol. Anal Calc. for C12H19NO2 : C, 68.86; H, 9.15; N, 6.67. Found: C, 68.73; H, 9.09; N, 6.85.

Workup

  1. additionwas dropped in
  2. customFor analysis, the pale yellow micro crystals which separated (0.45 g, 53%, m.p. 104°-106°)
  3. customwere recrystallized from aqueous ethanol

Sources & evidence

ORD record
ord-2660473e20834aa09ac5aef2db4fab5f
Source dataset
uspto-grants-1978_01
Patent number
US04070366

Reaction notes

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