Hydrochloric Acid → HCID 13426327, compound

HRID 1834475Notes

Reaction equation

HRID 1834475 reaction equation
O[C:2]1([CH2:17][C:18]#[N:19])[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[CH:6]=[CH:5][C:4]2[CH:13]=[CH:14][CH:15]=[CH:16][C:3]1=2.Cl>C(O)(C)C>[C:18]([CH:17]=[C:2]1[C:3]2[CH:16]=[CH:15][CH:14]=[CH:13][C:4]=2[CH:5]=[CH:6][C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]1=2)#[N:19]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 20373266HCID 20373266, compound

Product 1

HCID 13426327HCID 13426327, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

10 g. 5-hydroxy-5-cyanomethyl-5H-dibenzo-[a,d]-cycloheptene (0.0405 mol), prepared according to A, are heated to boiling for 1 hour in 150 ml. isopropanol saturated with hydrogen chloride. Subsequently, one evaporates the reaction mixture (residue 9.0 g., m.p. 137° - 138° ) and recrystallises the product from a petroleum fraction boiling at 100° - 140°. The analytically pure crystals melt at 143° - 144°, the yield amounts to 7.2 g. (79% of theory).

Workup

  1. temperatureare heated
  2. customSubsequently, one evaporates the reaction mixture (residue 9.0 g., m.p. 137° - 138° )
  3. customrecrystallises the product from a petroleum fraction boiling at 100° - 140°
  4. custommelt at 143° - 144°

Sources & evidence

ORD record
ord-a63e27856e7d4e68a03f6ab38705c994
Source dataset
uspto-grants-1978_01
Patent number
US04070373

Reaction notes

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