Ethyl formate → HCID 20372289, compound

HRID 1834863Notes

Reaction equation

HRID 1834863 reaction equation
[CH3:1][CH:2]([NH2:21])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]([F:20])([F:19])[C:10]([F:18])([F:17])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1.[CH2:22]([O:24]C=O)C>>[CH3:1][CH:2]([NH:21][CH:22]=[O:24])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]([F:19])([F:20])[C:10]([F:17])([F:18])[C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1

Participants

3

Reactant 2

HCID 8025Ethyl formateHCID 20372239HCID 20372239, compound

Product 1

HCID 20372289HCID 20372289, compound

Procedure

α-Methyl-2-(α,α,β,β-tetrafluorophenethyl)-benzylamine, 1.06 g. (0.00357 mole), in 50 ml. of ethylformate is stirred and heated to refluxing for about 21 hours. Evaporation of the solution to dryness and trituration of the residue with hexane gives N-[α-methyl-2-(α,α,β,β-tetrafluorophenethyl)-benzyl]-formamide, m.p. 94.5°-99° C. Recrystallizations from ether-petroleum ether and isopropyl alcohol-water afford a purified sample, m.p. 103°-105° C.

Workup

  1. temperatureheated
  2. temperatureto refluxing for about 21 hours
  3. customEvaporation of the solution to dryness and trituration of the residue with hexane

Sources & evidence

ORD record
ord-50512f78b37d4449b5f1312e3e86dba3
Source dataset
uspto-grants-1978_01
Patent number
US04071570

Reaction notes

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