反应详情

温度

20 °C

At about 20° C, 10.5 parts of triethylamine and subsequently 12.4 parts of methylmethoxycarbamoyl chloride are added to a suspension of 24.5 parts of 3-(3,5-dichlorophenyl)-hydantoin in 250 parts of dry tetrahydrofuran. After all has been added, the mixture is refluxed for 3 hours. After the mixture has been cooled to 20° C, the precipitated triethylamine hydrochloride is removed by suction filtration. The filtrate is concentrated. The residue is dissolved in a 1:1 mixture of n-pentane and ether, suction filtered, dried and recrystallized from toluene.

1. additionAfter all has been added
2. temperaturethe mixture is refluxed for 3 hours
3. customthe precipitated triethylamine hydrochloride is removed by suction filtration
4. concentrationThe filtrate is concentrated
5. dissolutionThe residue is dissolved in a 1:1 mixture of n-pentane and ether, suction
6. filtrationfiltered
7. customdried
8. customrecrystallized from toluene